Effects of droperidol, pentobarbital, and ketamine on myogenic transcranial magnetic motor-evoked responses in humans.
Identifieur interne : 004293 ( Main/Exploration ); précédent : 004292; suivant : 004294Effects of droperidol, pentobarbital, and ketamine on myogenic transcranial magnetic motor-evoked responses in humans.
Auteurs : C J Kalkman [États-Unis] ; J C Drummond ; P M Patel ; T. Sano ; R M ChesnutSource :
- Neurosurgery [ 0148-396X ] ; 1994.
Descripteurs français
- KwdFr :
- Adulte, Anesthésie générale, Champs électromagnétiques, Cortex moteur (), Dropéridol (pharmacologie), Humains, Kétamine (pharmacologie), Motoneurones (), Muscles squelettiques (innervation), Mâle, Pentobarbital (pharmacologie), Perfusions veineuses, Potentiels évoqués (), Surveillance peropératoire (instrumentation), Temps de réaction (), Transmission synaptique ().
- MESH :
English descriptors
- KwdEn :
- Adult, Anesthesia, General, Droperidol (pharmacology), Electromagnetic Fields, Evoked Potentials (drug effects), Humans, Infusions, Intravenous, Ketamine (pharmacology), Male, Monitoring, Intraoperative (instrumentation), Motor Cortex (drug effects), Motor Neurons (drug effects), Muscle, Skeletal (innervation), Pentobarbital (pharmacology), Reaction Time (drug effects), Synaptic Transmission (drug effects).
- MESH :
- chemical , pharmacology : Droperidol, Ketamine, Pentobarbital.
- drug effects : Evoked Potentials, Motor Cortex, Motor Neurons, Reaction Time, Synaptic Transmission.
- innervation : Muscle, Skeletal.
- instrumentation : Monitoring, Intraoperative.
- Adult, Anesthesia, General, Electromagnetic Fields, Humans, Infusions, Intravenous, Male.
Abstract
Myogenic motor-evoked responses to transcranial magnetic stimulation of the motor cortex (tcmag-MERs) may become clinically useful for the noninvasive assessment of motor pathway conduction during surgery. However, application is hindered because most anesthetic regimens result in severe depression of tcmag-MER amplitudes. As part of our systematic attempts to identify anesthetic agents and supplements suitable for use during tcmag-MER recording, we studied the effect of bolus doses of pentobarbital (1.5 mg/kg), droperidol (0.07 mg/kg), or ketamine (1 mg/kg), administered intravenously, on compound muscle action potentials to transcranial magnetic stimulation in five healthy volunteers. The doses were chosen to be comparable with doses that might be suitable for supplementation of a nitrous oxide/opioid anesthetic technique. Droperidol administration resulted in sustained amplitude depression of both tibialis and adductor pollicis tc-MERs to 30 +/- 9% and 39 +/- 14% of baseline (P < 0.01). Tcmag-MER amplitude changes after pentobarbital were variable, ranging from no change to substantial amplitude depression (to 20% of baseline) in two subjects. In contrast, ketamine administration did not result in significant amplitude depression. In three subjects, tibialis anterior amplitude increased to 150 to 220% of control values in the first 10 minutes after ketamine. Onset latency was unchanged after any drug. These data indicate that tcmag-MERs are moderately depressed after droperidol and pentobarbital but well preserved after ketamine. Ketamine may be a more suitable supplement to opioid/nitrous oxide anesthesia than droperidol or pentobarbital.
DOI: 10.1227/00006123-199412000-00008
PubMed: 7885550
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002853
- to stream PubMed, to step Curation: 002853
- to stream PubMed, to step Checkpoint: 002745
- to stream Ncbi, to step Merge: 002936
- to stream Ncbi, to step Curation: 002936
- to stream Ncbi, to step Checkpoint: 002936
- to stream Main, to step Merge: 004356
- to stream Main, to step Curation: 004293
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of droperidol, pentobarbital, and ketamine on myogenic transcranial magnetic motor-evoked responses in humans.</title><author><name sortKey="Kalkman, C J" sort="Kalkman, C J" uniqKey="Kalkman C" first="C J" last="Kalkman">C J Kalkman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology, University of California, San Diego.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Anesthesiology, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Drummond, J C" sort="Drummond, J C" uniqKey="Drummond J" first="J C" last="Drummond">J C Drummond</name></author><author><name sortKey="Patel, P M" sort="Patel, P M" uniqKey="Patel P" first="P M" last="Patel">P M Patel</name></author><author><name sortKey="Sano, T" sort="Sano, T" uniqKey="Sano T" first="T" last="Sano">T. Sano</name></author><author><name sortKey="Chesnut, R M" sort="Chesnut, R M" uniqKey="Chesnut R" first="R M" last="Chesnut">R M Chesnut</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:7885550</idno><idno type="pmid">7885550</idno><idno type="doi">10.1227/00006123-199412000-00008</idno><idno type="wicri:Area/PubMed/Corpus">002853</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002853</idno><idno type="wicri:Area/PubMed/Curation">002853</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002853</idno><idno type="wicri:Area/PubMed/Checkpoint">002745</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002745</idno><idno type="wicri:Area/Ncbi/Merge">002936</idno><idno type="wicri:Area/Ncbi/Curation">002936</idno><idno type="wicri:Area/Ncbi/Checkpoint">002936</idno><idno type="wicri:doubleKey">0148-396X:1994:Kalkman C:effects:of:droperidol</idno><idno type="wicri:Area/Main/Merge">004356</idno><idno type="wicri:Area/Main/Curation">004293</idno><idno type="wicri:Area/Main/Exploration">004293</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of droperidol, pentobarbital, and ketamine on myogenic transcranial magnetic motor-evoked responses in humans.</title><author><name sortKey="Kalkman, C J" sort="Kalkman, C J" uniqKey="Kalkman C" first="C J" last="Kalkman">C J Kalkman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology, University of California, San Diego.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Anesthesiology, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Drummond, J C" sort="Drummond, J C" uniqKey="Drummond J" first="J C" last="Drummond">J C Drummond</name></author><author><name sortKey="Patel, P M" sort="Patel, P M" uniqKey="Patel P" first="P M" last="Patel">P M Patel</name></author><author><name sortKey="Sano, T" sort="Sano, T" uniqKey="Sano T" first="T" last="Sano">T. Sano</name></author><author><name sortKey="Chesnut, R M" sort="Chesnut, R M" uniqKey="Chesnut R" first="R M" last="Chesnut">R M Chesnut</name></author></analytic><series><title level="j">Neurosurgery</title><idno type="ISSN">0148-396X</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anesthesia, General</term><term>Droperidol (pharmacology)</term><term>Electromagnetic Fields</term><term>Evoked Potentials (drug effects)</term><term>Humans</term><term>Infusions, Intravenous</term><term>Ketamine (pharmacology)</term><term>Male</term><term>Monitoring, Intraoperative (instrumentation)</term><term>Motor Cortex (drug effects)</term><term>Motor Neurons (drug effects)</term><term>Muscle, Skeletal (innervation)</term><term>Pentobarbital (pharmacology)</term><term>Reaction Time (drug effects)</term><term>Synaptic Transmission (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Anesthésie générale</term><term>Champs électromagnétiques</term><term>Cortex moteur ()</term><term>Dropéridol (pharmacologie)</term><term>Humains</term><term>Kétamine (pharmacologie)</term><term>Motoneurones ()</term><term>Muscles squelettiques (innervation)</term><term>Mâle</term><term>Pentobarbital (pharmacologie)</term><term>Perfusions veineuses</term><term>Potentiels évoqués ()</term><term>Surveillance peropératoire (instrumentation)</term><term>Temps de réaction ()</term><term>Transmission synaptique ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Droperidol</term><term>Ketamine</term><term>Pentobarbital</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Evoked Potentials</term><term>Motor Cortex</term><term>Motor Neurons</term><term>Reaction Time</term><term>Synaptic Transmission</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Monitoring, Intraoperative</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Dropéridol</term><term>Kétamine</term><term>Muscles squelettiques</term><term>Pentobarbital</term><term>Surveillance peropératoire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Anesthesia, General</term><term>Electromagnetic Fields</term><term>Humans</term><term>Infusions, Intravenous</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Anesthésie générale</term><term>Champs électromagnétiques</term><term>Cortex moteur</term><term>Humains</term><term>Motoneurones</term><term>Mâle</term><term>Perfusions veineuses</term><term>Potentiels évoqués</term><term>Temps de réaction</term><term>Transmission synaptique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Myogenic motor-evoked responses to transcranial magnetic stimulation of the motor cortex (tcmag-MERs) may become clinically useful for the noninvasive assessment of motor pathway conduction during surgery. However, application is hindered because most anesthetic regimens result in severe depression of tcmag-MER amplitudes. As part of our systematic attempts to identify anesthetic agents and supplements suitable for use during tcmag-MER recording, we studied the effect of bolus doses of pentobarbital (1.5 mg/kg), droperidol (0.07 mg/kg), or ketamine (1 mg/kg), administered intravenously, on compound muscle action potentials to transcranial magnetic stimulation in five healthy volunteers. The doses were chosen to be comparable with doses that might be suitable for supplementation of a nitrous oxide/opioid anesthetic technique. Droperidol administration resulted in sustained amplitude depression of both tibialis and adductor pollicis tc-MERs to 30 +/- 9% and 39 +/- 14% of baseline (P < 0.01). Tcmag-MER amplitude changes after pentobarbital were variable, ranging from no change to substantial amplitude depression (to 20% of baseline) in two subjects. In contrast, ketamine administration did not result in significant amplitude depression. In three subjects, tibialis anterior amplitude increased to 150 to 220% of control values in the first 10 minutes after ketamine. Onset latency was unchanged after any drug. These data indicate that tcmag-MERs are moderately depressed after droperidol and pentobarbital but well preserved after ketamine. Ketamine may be a more suitable supplement to opioid/nitrous oxide anesthesia than droperidol or pentobarbital.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>San Diego</li></settlement></list><tree><noCountry><name sortKey="Chesnut, R M" sort="Chesnut, R M" uniqKey="Chesnut R" first="R M" last="Chesnut">R M Chesnut</name><name sortKey="Drummond, J C" sort="Drummond, J C" uniqKey="Drummond J" first="J C" last="Drummond">J C Drummond</name><name sortKey="Patel, P M" sort="Patel, P M" uniqKey="Patel P" first="P M" last="Patel">P M Patel</name><name sortKey="Sano, T" sort="Sano, T" uniqKey="Sano T" first="T" last="Sano">T. Sano</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Kalkman, C J" sort="Kalkman, C J" uniqKey="Kalkman C" first="C J" last="Kalkman">C J Kalkman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004293 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004293 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:7885550
|texte= Effects of droperidol, pentobarbital, and ketamine on myogenic transcranial magnetic motor-evoked responses in humans.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:7885550" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |